Travis Trice score 12 points in Michigan State's (12-3, 1-1 Big Ten) conference home opener.
Branden Dawson added 14 points and 11 rebounds for the Spartans, who blew the game open with 48 points after posting a close 36-30 lead at the break. Keith Appling had six points but also notched a season-high eight assists.
A.J. Hammons led Purdue (7-7, 1-1) with 20 points and seven rebounds. D.J. Byrd scored 14 for the Boilermakers.