Mason Plumlee added 13 points and a dozen rebounds, and Rasheed Sulaimon scored 12 for the Blue Devils (14-0, 1-0 ACC).
Travis McKie scored 22 points and C.J. Harris tallied 19 for Wake Forest (7-6, 0-1). The Demon Deacons had a three-game winning streak halted.
Duke hit seven of its first eight tries from 3-point range and finished 11-of-22 from beyond the arc. Duke shot 46 percent from the field to 41.1 percent for Wake Forest.
The Blue Devils opened the second half with an 18-6 run.