Gregory Echenique scored 13 points and grabbed 14 boards as the Bluejays (12-1, 1-0 MVC) began conference play with a sixth straight win.
Jahenns Manigat (13 points) and Avery Dingman (11) also made offensive contributions for Creighton.
Troy Taylor notched a triple-double of 10 points, 10 rebounds and 10 assists, but it wasn't enough for the Purple Aces (7-6, 0-1).
Colt Ryan led Evansville with 25 points.
Celebrity Breakups and divorces of 2014 [PHOTOS]