The Hoosiers took a 15-point halftime lead and held Jacksonville to three points during a 10-minute stretch of the second period.
Indiana hit 50 percent from the field and connected on 11-of-25 shots from beyond the arc. Cody Zeller scored 16 points for Indiana (12-1) and both Will Sheehey and Victor Oladipo had 14.
It was the final non-conference game of the regular season for Indiana, which opens Big Ten play on Monday with a visit to Iowa.
Jacksonville (5-8) was led by Dylan Fritsch with 15 points.