Arizona used a 16-6 run capped by a Lyons 3-pointer to produce 56-37 bulge midway through the second half when the Hurricanes shot only 33.3 percent from the field. The Wildcats made 8-of-18 3-pointers and held a 46-20 rebounding edge for the game.
The Wildcats (11-0), who also got 12 points from Nick Johnson and 11 from Kevin Parrom, will face No. 15 San Diego State for the tourney title on Christmas Day.
Kaleb Tarczewski pulled down 13 rebounds to go with eight points to help Coach Sean Miller notch his 200th career win.
Kenny Kadji led the Hurricanes (8-2) with 19 points. Durand Scott added 15 points, but had five of Miami's nine turnovers.
Shane Larkin put in10 points and carded six steals for Miami, which lost for the first time in eight games.