Louisville coach Rick Pitino met his son, Richard, who guided Golden Panthers.
The Cardinals steadily built their lead to 14 points through one half with Blackshear contributing four 3-pointers.
Peyton Siva added 15 points and 12 assists. Chane Behanan delivered 14 points and 11 rebounds for the Cardinals (10-1). Louisville won its fifth straight.
Tymell Murphy and Malik Smith both scored 12 points for Florida International with Murphy also pulling down 12 rebounds.