All but one of undefeated Arizona's (9-0) starters was in double figures as the Wildcats shot a sizzling 57.6 percent from the field and out-rebounded Oral Roberts (5-5) 34-23.
Lyons opened the game with a 3-pointer that sparked a 10-2 run that put the Wildcats firmly in control. Arizona led 45-31 at halftime.
Warren Niles led the Golden Eagles with 22 points, including 5-of-7 shots from 3-point range. Shawn Glover added 18. Oral Roberts' two-game winning streak was snuffed out.