The Spartans (8-3) used a 15-5 run early in the second frame to grab the lead for good, though they had to turn back a late Ramblers rally.
Adreian Payne contributed a double-double of 14 points and 10 rebounds, and Keith Appling helped out with eight points and seven assists as MSU posted its third straight win.
Loyola (6-3) got 25 points and eight rebounds from Ben Averkamp.
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