Smith passed out five assists, recorded five steals and went 12-of-18 from the field for the Cardinals (8-1), who posted their third straight victory.
Luke Hancock added 15 points, six boards and five assists, while Montrezl Harrell supplied 14 points and seven rebounds for Louisville.
Trinity Hall led the Kangaroos (4-5) with nine points.
Jessica Simpson shares three-way kiss with friends in photo
Teacher apologizes for showing sexual image of herself in class