Four Kentucky (6-3) starters scored in double figures and Ryan Harrow led the reserves with eight points.
The Wildcats went on a 16-0 run in the first half to break a 10-10 tie and start pulling away from the Pilots (3-6).
Kentucky shot 53.1 percent from the field in the second half to maintain control of the game.
Portland, which lost its third in a row, shot 27.1 percent for the game and was hampered by 18 turnovers.
Ryan Nicholas led the Pilots with 15 points and a game-high 13 rebounds.