Christian Watford helped out with 19 points and Victor Oladipo turned in an all-around game of 15 and nine rebounds for the undefeated Hoosiers (9-0).
Indiana grabbed control of the game with a 29-4 run in the first half, connecting on 54.2 percent of its shots from the floor.
Sophomore forward Austin Etherington was taken off the court on a stretcher when he appeared to injure his left knee late in the first half.
Central Connecticut State (4-4) was led by Matt Hunter with 40 points.
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