New Mexico was rolling to what appeared to be an easy victory when it held a 70-55 lead with less than 8 minutes remaining.
The Lobos, however, went scoreless for more than 5 minutes and the Trojans climbed within 70-65.
Williams then hit his key 3-pointer with 1:52 to play and the Trojans could score just two more points the rest of the way.
New Mexico has won all of its nine games this season while USC dropped to 3-5.
Hugh Greenwood led the Lobos with 17 points while both Williams and Alex Kirk had 13. New Mexico hit 50 percent of its field goal attempts and was 11-of-24 from 3-point range.
Eric Wise scored 14 points for USC, which placed all five of its starters in double figures.
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