Oklahoma State held the Bulls without a point for a 5-minute stretch early in the second half while building a 12-point lead.
The Cowboys (6-1) rebounded from their first loss of the season, a 10-point setback against Virginia Tech on Saturday. Markel Brown added 13 points for the Cowboys while Philip Jurick claimed 15 rebounds.
South Florida (5-3) had won its previous three games. Victor Rudd had 14 points for the Bulls while Anthony Collins scored 12.
Man behind Doritos Locos Tacos passed away on Thanksgiving
Kate Moss Playboy shoot is classic Playboy, classic Kate