Nerlens Noel added 13 points with five blocked shots and Willie Cauley-Stein chipped in with 12 points off the bench for the Wildcats (5-3), who rebounded from a home loss to Baylor Saturday -- their first under Coach John Calipari.
Julius Mays also reached double figures with 10 points for Kentucky, which dominated the game from the opening tip.
Samford (2-8) was led by Raijon Kelly with 14 second-half points.
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