Will Artino and Ethan Wragge helped out 13 points apiece for Creighton (4-0), which at one time held a 50-point advantage in the one-sided contest.
The Bluejays now advance to the tournament quarterfinals Friday in Las Vegas, where they will face Wisconsin.
Longwood (0-4) was paced by Jeylani Dublin, who provided 19 points and eight rebounds in the loss.
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