Smith also provided five steals, while Peyton Siva contributed 10 points and eight assists for the Cardinals (1-0), who are coming off their run to the Final Four in last season's NCAA Tournament.
Kevin Ware also reached double figures with 10 points for Louisville.
The Jaspers (0-1) got 18 points and 14 rebounds from Rhamel Brown.
Rosie O'Donnell unveils nearly 50-pound weight loss
Members of Congress to keep receiving porn magazine