A.J. Walton and Anthony Jones each scored 13 points for the Bears (25-5, 12-5 Big 12), who held the Red Raiders to 15 first-half points.
Baylor's victory was a school-record 12th in a Big 12 Conference season.
Texas Tech (8-21, 1-16) got 19 points from Jordan Tolbert in its 16th loss in 17 games.
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