Fab Melo contributed 11 points, including a go-ahead dunk with 25 seconds left, and grabbed nine rebounds as Syracuse (29-1, 16-1 Big East) won its ninth straight game.
Orange Coach Jim Boeheim collected his 400th career Big East win in the conference-clinching victory.
The Huskies (17-11, 7-9) were led by Jeremy Lamb's 19 points, while Andre Drummond provided 15 points and 13 rebounds.
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