Michael Dixon contributed 15 points and six assists while Marcus Denmon added 14 points and six rebounds for the Tigers, (25-2, 12-2 Big 12), who notched their first road win over the Aggies since 2001.
Phil Pressey chipped in with 13 points and seven assists for Missouri, which went on a 22-11 second-half surge to put the game away.
The Aggies (13-13, 4-10) were led by Khris Middleton's 15 points.
Jordan Green added 14 on 6-of-8 shooting in the loss.
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