The Bulldogs won for the fourth time in five games and moved into a tie for third place with Vanderbilt in the Southeastern Conference behind Kentucky and Florida.
Mississippi State scored the game's first eight points, opened a 40-27 halftime lead and built an 18-point cushion early in the second period.
Arnett Moultrie scored 18 points for the Bulldogs (19-5, 6-3 SEC), Renardo Sidney added 14 and Rodney Hood contributed 10.
Reginald Buckner had 15 points to pace Mississippi (14-0, 4-5).
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