Scott made all nine of his attempts as part of a 53-percent Virginia shooting performance. Joe Harris added 11 points for the Cavaliers (19-4, 6-3 Atlantic Coast Conference), who rebounded from a three-point loss at Florida State on Saturday.
Travis McKie had 16 points and six rebounds for Wake Forest (11-13, 2-8), which has lost five in a row.
The Deacons made only 14 shots from the field and suffered 17 turnovers.
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