Jamil Wilson and Jae Crowder combined for 32 points and 20 rebounds for Marquette (20-5, 9-3 Big East), which bounced back from a 17-point Saturday loss at Notre Dame.
The Golden Eagles started slowly but overcame a 12-point deficit thanks in part to 16 points from Vander Blue and 10 more from Junior Cadougan.
DePaul (11-12, 2-9) was led by Cleveland Melvin with 22 points.
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