Duke is one home victory away from equaling the school record set during a four-year period beginning in 1997.
The Blue Devils, who led by as many as 15 points in the first half, are unbeaten in the Atlantic Coast Conference.
Dawkins hit seven of Duke's 11 3-pointers and the Blue Devils shot 53 percent from the field overall. Austin Rivers added 20 points off the bench for Duke (16-2, 4-0 ACC) and Ryan Kelly, another bench player, chipped in 20 points and 10 rebounds.
C.J. Harris led Wake Forest (10-8, 1-3) with 20 points. The Demon Deacons attempted 17 3-pointers and made just three. The physical game resulted in 46 fouls being called.