Shabazz Napier scored 16 points to lead the Huskies (14-3, 4-2 Big East), who had also snapped Notre Dame's previous 45-game winning streak in South Bend back in 2009.
Notre Dame led at halftime 25-24, but was outscored 43-28 in the second half.
Eric Atkins led Notre Dame (11-7, 3-2) with 20 points. Scott Martin scored 12 and had nine rebounds.
Rebounds played a big role in the game as both teams shot under 47 percent from the field. The Huskies had 47 boards to 30 for the Irish.
Notable deaths of 2014 [PHOTOS]