The Orange have won their first 13 games of the season and will embark on Big East Conference play next Wednesday when they host Seton Hall.
Syracuse had only a 22-19 lead with 7 minutes to go in the opening half but the Green Wave did not score another point before intermission. The Orange lead grew to 41-19 at the half.
Kris Joseph added 13 points for Syracuse, which hit 50 percent of its shots from the field and made 18-of-22 free throw attempts.
Kendall Timmons scored 16 points for Tulane, which made a mere 16 field goals for the entire game. The Green Wave slipped to 11-2, their only other loss having come Dec. 6 at Wofford.