Pittsburgh (7-1) also got 16 points from Ashton Gibb and eight points apiece from Lamar Patterson, Dante Taylor and John Johnson.
The victory was the Panthers' fifth straight since a Nov. 16 upset loss to Long Beach State.
The Volunteers (3-4), meanwhile, lost for the fourth time in five games.
Cameron Tatum led Tennessee with 13 points and 10 rebounds.
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