Holloway connected on a pair of 3-pointers and canned four foul shots in the extra frame, in which the Muskateers (5-0) outscored Vanderbilt 16-4.
Holloway grabbed five rebounds and distributed four assists while Mark Lyons added 19 points and four steals in Xavier's ninth win in 10 games against opponents from the SEC.
John Jenkins netted 20 points to lead the Commodores (5-2).
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