Chane Behanan added 13 points and grabbed seven rebounds while Russ Smith and Peyton Siva each chipped in with 11 for the Cardinals (6-0).
Louisville forced 21 turnovers and sped out to a 44-32 halftime lead before cruising home for the victory.
Larry Anderson led the 49ers (3-3) with 17 points while Casper Ware added 13 points and eight assists.
Gal Gadot cast as Wonder Woman for 'Batman vs. Superman'
Toddler uninjured after being knocked over by Obama family dog