Chane Behanan added 13 points and grabbed seven rebounds while Russ Smith and Peyton Siva each chipped in with 11 for the Cardinals (6-0).
Louisville forced 21 turnovers and sped out to a 44-32 halftime lead before cruising home for the victory.
Larry Anderson led the 49ers (3-3) with 17 points while Casper Ware added 13 points and eight assists.
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