The deal is reportedly worth $36 million, including $20 million in guaranteed money. Casey is now the highest paid player on the Titans.
"We are excited to come to an agreement on an extension with Jurrell," said Titans general manager Ruston Webster. "This is something Jurrell has earned not only with his play on the field but his work ethic as well. We appreciate Jurrell's professionalism through this process and look forward to many good years to come."
Casey has been a solid starter for the Titans since they selected him in the third round of the 2011 NFL Draft. The USC product has recorded 161 tackles, 16 sacks, four forced fumbles and two fumble recoveries in 47 games (45 starts).
The 24-year-old Casey had 55 tackles and 10 1/2 sacks in 2013.