Price, the 2012 AL Cy Young Award winner, has not lived up to his lofty standards this season at just 4-6 with a 3.97 ERA. He does, however, rank second in the majors with 111 strikeouts while walking a mere 10 in 99 2/3 innings.
The southpaw lasted eight innings in his most recent start on June 9 while striking out 10, but he gave up three runs and was the hard-luck loser against the Mariners.
Price has allowed 105 hits this season, the most in the bigs.
The Astros will send Brad Peacock to the hill. The third-year hurler is 2-4 with a 4.50 ERA in 13 appearances (nine starts).
Peacock has turned things around of late, going 2-0 over his past four starts while boasting a 2.66 ERA over the span. He yielded just one earned run in six innings on June 10 in a no-decision against the Diamondbacks.
The 26-year-old right-hander has struggled at Minute Maid Park this season with a 5.18 ERA in 41 2/3 innings.
Houston managed to even the series on Saturday afternoon by capturing a 7-3 victory.
The Astros struck big with a five-run third inning, which was highlighted by a three-run double off the bat of Matt Dominguez. Dominguez finished 2-for-4 with those three RBI, Marwin Gonzalez was 3-for-4 with two runs scored and Dexter Fowler added a pair of RBI out of the leadoff spot.
Jarred Cosart (6-5) scattered nine hits and three earned runs but toughed out seven innings to earn the victory.
"I felt terrible in the third inning," said Cosart, who was battling a case of food poisoning. "I thought, 'I'm not going to make it.' But you keep pushing yourself. It's the competitive side. I didn't want to come out of the game. I didn't want to tax the bullpen and I guess I wasn't dying, so I was able to pitch."
Chris Archer (3-4) was not at his sharpest for the Rays, allowing three hits and three walks in just three innings of work, but of the six runs he allowed, only one was earned.
Evan Longoria provided the bulk of Tampa Bay's offense, going 2-for-4 with a homer, his eighth of the season, and three RBI.
Tampa Bay was 5-2 against Houston last season.