After mustering a mere one run during a three-game series in Baltimore that concluded a 2-7 road trip -- which began with three losses to the Indians -- the Red Sox totaled 12 hits to support 7 2/3 effective innings from Jon Lester.
Ortiz swatted a two-run homer, Holt doubled in a pair as part of a 2-for-4 night and Daniel Nava finished with three hits in the victory.
Lester (7-7) did his part as well, scattering eight hits while holding Cleveland to two runs, only one of which was earned.
Josh Tomlin (4-3) was saddled with the loss, the Indians' third straight following a 9-1 stretch, after being reached for four runs -- three earned -- on nine hits over 5 2/3 innings.
Jason Kipnis went 2-for-4 with a two-run single to pace Cleveland offensively.