After Chicago fumbled away the opener of this series, Noesi will try to find the win column on Tuesday night as the White Sox play the second of three straight meetings with the Los Angeles Dodgers.
The right-handed Noesi has not picked up a Major League victory since May 6, 2012 while with the Seattle Mariners. He has made 40 appearances since and lost 14 straight decisions and is already on his third team of 2014.
Noesi opened with the Mariners before moving on to the Texas Rangers, who placed the 27-year-old on waivers, where he was selected by the White Sox on April 25.
Noesi has made seven appearances with Chicago since, including six straight starts, and certainly pitched well enough to win on Wednesday versus Cleveland. Instead, he got a no-decision despite giving up one run on five hits over 7 1/3 innings, striking out five without a walk.
Now 0-4 with a 5.83 earned run average in 12 total games this season, Noesi is set to face the Dodgers for the first time and hopes to avoid some of the luck that plagued fellow starter Jose Quintana in Monday's opener.
Quintana had held the Dodgers to just two hits going into the sixth inning, but Los Angeles put up five unearned runs in the frame off of him thanks to a pair of errors en route to a 5-2 win.
"Tonight wasn't a good night defensively," White Sox manager Robin Ventura said. "Jose deserved a better fate."
Dodgers starter Clayton Kershaw began the frame with a single and Matt Kemp later reached on a one-out error by Gordon Beckham.
After Yasiel Puig struck out, Hanley Ramirez reached base on Conor Gillaspie's throwing error that scored a run and opened up the flood gates. Adrian Gonzalez, Justin Turner and Drew Butera all had two-out hits and scored runs in the frame.
Kershaw struck out nine over eight innings and earned the win. The reigning Cy Young Award winner surrendered four hits -- the only costly one a two-run homer by the newly-activated Jose Abreu.
"Clayton was dominant tonight, only one bad pitch," Dodgers manager Don Mattingly said.
Abreu, sidelined since May 18 with tendinitis in his left ankle, was reinstated from the disabled list Monday and made his presence known, following a fourth-inning single by Beckham with his 16th homer of the season.
Still, the White Sox lost for the third time in four games while the Dodgers picked up only their second win in six contests.
Los Angeles will start Dan Haren, who is winless in his last three games and 5-3 with a 3.28 ERA on the year.
Haren followed up consecutive losses with a no-decision versus Pittsburgh on Thursday. He yielded three runs on eight hits -- two of them homers -- over six innings of work.
The 33-year-old righty is 3-1 in his career versus the White Sox with a 3.76 ERA.
The Dodgers won two of three over the visiting White Sox in the last meeting in 2012.