Michael Brantley added three hits and also drove in three runs for the Tribe, which took three of four in this set. Both Brantley and Cabrera ended a triple shy of the cycle.
Cleveland starter Justin Masterson (2-1) picked up the win, allowing four runs -- two earned -- on four hits in 6 1/3 innings. The right-hander walked four and struck out seven, helping the Indians go 5-2 during a seven-game homestand.
Josmil Pinto had two hits and Chris Colabello drove in a pair for the Twins, who have dropped three in a row after taking the series opener.