San Antonio's magic number to clinch the best record in the NBA is down to three.
The Grizzlies fell into ninth place in the Western Conference standings, a half-game behind Phoenix for the final playoff spot. The Suns are currently doing battle with the Thunder.
San Antonio's defense was the story in the first quarter, as the reigning Western Conference champs held the Grizzlies to just 10 points on 5-of-22 shooting. Tony Parker, who played just nine minutes before leaving with back spasms, matched the visitors with 10 by himself on 4-of-4 shooting from the floor. The Spurs led 26-10 after one.
The Grizzlies got as close as six late in the second, but Ginobili countered with a 3-pointer and Cory Joseph's jumper restored a double-digit margin. It was 51-38 as the seconds trickled down, and Leonard stepped into a 3-ball and beat the buzzer for a 16-point halftime advantage.
Any hopes of a Memphis comeback went away early in the third quarter, as all five of the Spurs' second-half starters scored during a 17-9 spurt that spanned just over four minutes.
The lead never dipped back into single digits the rest of the way.