Heisey's pinch-hit single in the ninth inning scored Ryan Ludwick to lift the Reds to a 1-0 win over the St. Louis Cardinals in a rain-delayed game that was dominated until the end by good pitching.
Ludwick and Frazier led off the ninth with back-to-back singles off Cardinals right-hander Carlos Martinez and both moved up on Zack Cozart's bunt. After Martinez (0-1) intentionally walked Brayan Pena, Heisey laced an 0-1 fastball into left field and was mobbed by his teammates in the infield.
There were only six total hits in the game before Cincinnati's three singles in the ninth.
Reds left-hander Tony Cingrani and Cardinals righty Michael Wacha combined to strike out 16 batters and allow only five hits in 13 2/3 combined innings after the start of the game was delayed 2 hours and 40 minutes because of rain.
The Cardinals won the season-opener 1-0 on Monday on Yadier Molina's home run in the seventh. The finale of the three-game series was scheduled to start 12 hours after the finish of Wednesday night's game at 12:35 a.m.