Monroe poured in a game-high 28 points to go with 14 rebounds, Jennings scored 20 points and dished out 13 assists and Drummond chipped in with 10 points and 16 boards for the Pistons, who snapped a three-game skid.
Josh Smith added 26 points for Detroit.
Monday's game pitted Jennings and Knight against their former teams. Jennings, who was selected by Milwaukee with the 10th pick in the 2009 NBA Draft, spent his first four seasons with the Bucks. The Pistons took Knight with the eight overall pick in the 2011 NBA Draft. He signed with the Bucks this past offseason.