Chris Kunitz and Beau Bennett scored goals in the third period for the Penguins, who had dropped six of eight coming into the contest.
With 99 points, Pittsburgh is all but guaranteed of winning the Metropolitan Division thanks to a 13-point lead over the New York Rangers, and both clubs have eight games to play. Pittsburgh is seven points back of idle Boston for the top spot in the Eastern Conference.
James Wisniewski scored the only goal of the game for the Blue Jackets, who have dropped three of their last four but are still hanging on to the top wild card spot.
Columbus, Detroit, Washington and Toronto all have 80 points, but Columbus holds the tiebreaker to lay claim to the first wild card.