Danny Green hit 5-of-9 from distance en route to 16 points, while Tony Parker, Tiago Splitter and Manu Ginobili all donated 10 points as the Spurs extended the NBA's longest current winning streak to 15 games.
San Antonio has won both meetings this season over the Nuggets with a chance to complete the season-sweep on Friday in Denver.
Aaron Brooks paced Denver with 25 points and eight assists off the bench. Kenneth Faried and Timofey Mozgov each posted double-doubles, with Faried totaling 24 points and 10 rebounds while Mozgov finished with 14 points and 11 boards.
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