Lundqvist's effort was supported by goals from Derek Dorsett, Ryan McDonagh and Dominic Moore and ran the Rangers' win streak to a season-high five games.
The result also moved New York three points ahead of the Flyers for second place in the division, though Philadelphia still has two games in hand.
Lundqvist took a shutout deep into the third period before Jakub Voracek spoiled the bid with 1:53 remaining.
Steve Mason stopped 26 shots in the loss, the Flyers' eighth straight in regulation at Madison Square Garden since a 4-2 decision over the Blueshirts on Feb. 20, 2011.
Notable deaths of 2014 [PHOTOS]