The Clippers picked up win No. 50 on the season for the second straight season and just the second time in franchise history.
Darren Collison scored 15 points with six assists and Chris Paul dropped in 14 points with seven assists for Los Angeles, which won for the eighth straight time at Staples Center and have taken 13 of its last 14 overall.
Ramon Sessions netted a season-high 28 points for the Bucks, who lost for the eighth straight game.
Zaza Pachulia and Jeff Adrien each scored 14 points in the setback.