Arizona's stifling defense swarmed Gonzaga, quickly turning each of its miscues into easy baskets the other way.
Aaron Gordon filled the stat sheet with 18 points, six rebounds, six assists and four steals and the Wildcats thrashed Gonzaga, 84-61, in the third round of the NCAA Tournament.
Top-seeded Arizona (32-4) tallied 15 steals and scored 31 points off 21 Bulldogs turnovers.
Rondae Hollis-Jefferson netted 18 points, while Nick Johnson had 17 points, five boards and five assists for the Wildcats, who will face San Diego State in a West Regional semifinal on Thursday in Anaheim.
Przemek Karnowski supplied 14 points and 10 rebounds to lead eighth-seeded Gonzaga (29-7), which beat Oklahoma State in the second round.