Joakim Noah scored 20 points with eight rebounds as Chicago grabbed their second win over Philadelphia this week and extended the 76ers franchise-record losing streak with a 91-81 decision on Saturday.
Chicago has won four of its last six contests.
Thaddeus Young scored a game-high 28 points and Henry Sims netted 18 with a career-high 15 rebounds in the setback.
The Sixers had their losing streak extended to 24 games, two shy of the NBA record set by the Cleveland Cavaliers in 2010-11. They will wrap up their three-game road trip in San Antonio and Houston before heading home to play Detroit with a possible NBA record on the line.
Philadelphia entered the game tied for the second-longest single-season losing skid in NBA history with Vancouver (1995-96), Denver (1997-98) and Charlotte (2011-12).