After Melky Cabrera's RBI double, Encarnacion hit a three-run homer and Sierra added a solo blast to make it 5-0.
All five runs came against Tigers left-hander Kyle Lobstein, who gave up eight hits and a walk in three innings. Lobstein struck out four.
Toronto right-hander Todd Redmond had eight strikeouts in six innings and gave up four runs -- three earned -- on five hits and a walk.
Ezequiel Carrera had a solo homer in Detroit's four-run sixth inning.