The A's sent 15 batters to the plate in the first inning. Nine faced White Sox starter Jose Quintana, who failed to get an out and was charged with all nine runs on seven hits and two walks.
Conor Gillaspie and Tyler Flowers hit solo homers off Oakland starter Jesse Chavez, who went 4 2/3 innings. Chavez allowed six hits and two walks with two strikeouts.
Jordan Danks hit two homers for Chicago and knocked in three.