With the score tied at 3-3 and two on, Matt Field ripped a single that bounced off pitcher Blaine Boyer and Alberto Gonzalez's wild throw allowed Yem Prades to score the go-ahead run. Bocock grounded out to third, but it allowed Paredes to score and Merrifield laced a base hit left that plated Fields to cap the inning.
Jason Donald added a two-run homer and Carlos Peguero stroked a solo shot for the Royals, who saw starter Jason Vargas surrender three runs on four hits over five innings.
Kyle Blanks hit a two-run homer and Yonder Alonso added a solo blast for the Padres. Ian Kennedy allowed four runs on eight hits over 4 2/3 innings.