Matt Duchene and Ryan O'Reilly picked up a goal and assist each for the Avalanche, winners in six of their last seven to vault over their Wednesday opponents into second place in the Central Division.
Brad Malone added a tally as Colorado won three of four in the season series from the defending Stanley Cup champions.
Patrick Kane and Brandon Saad scored for the Blackhawks, who saw a two-game win streak halted. Antti Raanta made 26 saves in defeat.
Celebrity Families of 2014 [PHOTOS]