McDermott led a shooting clinic by Creighton from the perimeter, draining 7- of-10 attempts from 3-point range in his 32 minutes of time. The Bluejays finished a sizzling 14-of-22 as a team from beyond the arc, with Jahenns Manigat accounting for four of those makes in a 14-point effort.
The win propels the second-seeded Bluejays (25-6), a first-year member of the realigned Big East, into Friday's semis against the winner of Thursday's final quarterfinal between Xavier and Marquette.
DePaul (12-21), the tournament's 10th seed coming off an opening-round upset of Georgetown, was paced by Brandon Young's 22 points and eight rebounds.
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