Andrew Cogliano scored 3:39 into the contest for the game's only goal, which was all the Ducks needed to post a second straight win.
Anaheim head Coach Bruce Boudreau notched his 300th career victory.
Brian Elliot turned aside 18-of-19 shots the Blues, who dropped a second straight following the Olympic break.
Former Titans kicker dies in car crash
UPI Sports Results for September 20, 2014