Durant netted 30 of his total in the second half, including a baseline jumper in the final 3 minutes that helped turn back a late Grizzlies surge and another with 33.3 seconds left to seal the outcome.
Russell Westbrook provided 21 points and six assists.
Serge Ibaka helped out with 16 points and nine rebounds for OKC.
Mike Miller erupted for 19 points in the fourth quarter to fuel the Grizzlies' late comeback try, but it wasn't enough as Memphis fell for the second time in three games.
Zach Randolph totaled 13 points and 10 rebounds.